uncompetitive - significado y definición. Qué es uncompetitive
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Qué (quién) es uncompetitive - definición

TYPE OF ENZYME INHIBITION
Uncompetitive inhibiton; Anticompetitive inhibitor; Anticompetitive inhibiton; Uncompetitive inhibitor
  • NMDA Inhibitor Memantine

uncompetitive      
¦ adjective not competitive or marked by fair competition.
Derivatives
uncompetitively adverb
uncompetitiveness noun
Uncompetitive inhibition         
Uncompetitive inhibition, also known as anti-competitive inhibition, takes place when an enzyme inhibitor binds only to the complex formed between the enzyme and the substrate (the E-S complex). Uncompetitive inhibition typically occurs in reactions with two or more substrates or products.
NMDA receptor         
  • Cartoon representation the human NMDA receptor. Each subunit is individually rainbow colored.
  • '''Figure 5:''' Chemical structures of memantine (right) and amantadine (left).
  • NR2 subunit in vertebrates (left) and invertebrates (right). Ryan et al., 2008
  • '''Figure 1:''' NR1/NR2 NMDA receptor
  • '''Figure 4:''' The chemical structures of MK-801, phencyclidine and ketamine, high affinity uncompetitive NMDA receptor antagonists.
  • left
  • '''Figure 6:''' Chemical structure of neramexane, second generation memantine derivative.
  • '''Figure 7:''' Nitroglycerin donate ONO<sub>2</sub> group that leads to second generation memantine analog, nitromemantine.
  • '''Figure 8:''' Structure activity relationship (SAR) of amantadine and related compounds
GLUTAMATE RECEPTOR AND ION CHANNEL PROTEIN FOUND IN NERVE CELLS
NMDA channel; NMDAR; NR1; NR2A; NR2C; NR2D; NR3B; NR3C; NR3A; NR2; Nmda channel; Nmda receptor; NMDA-receptor; N-methyl-D-aspartate receptor; Receptors, n-methyl-d-aspartate; NMDA Receptor; Nr2b; Nmethyl-D-aspartate; NMDA receptors; Glycine site; Phencyclidine site; Phencyclidine receptor; PCP receptor; PCP site; Glycine-site; Draft:Discovery and development of memantine and related compounds; uncompetitive NMDA receptor antagonists; User:Tinktura1/Discovery and development of memantine and related compounds; uncompetitive NMDA receptor antagonists; Discovery and development of memantine and related compounds; NMDA glutamate receptor; N-Methyl-D-aspartate receptor; PCP site 1; N-methyl-D-aspartate receptors; N-methyl D-aspartate receptor; GluN1 subunit; NMDA-type glutamate receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors.

Wikipedia

Uncompetitive inhibition

Uncompetitive inhibition, also known as anti-competitive inhibition, takes place when an enzyme inhibitor binds only to the complex formed between the enzyme and the substrate (the E-S complex). Uncompetitive inhibition typically occurs in reactions with two or more substrates or products.

While uncompetitive inhibition requires that an enzyme-substrate complex must be formed, non-competitive inhibition can occur with or without the substrate present.

Uncompetitive inhibition is distinguished from competitive inhibition by two observations: first uncompetitive inhibition cannot be reversed by increasing [S] and second, as shown, the Lineweaver–Burk plot yields parallel rather than intersecting lines. This behavior is found in the inhibition of acetylcholinesterase by tertiary amines (R3N). Such compounds bind to the enzyme in its various forms, but the acyl-intermediate-amine complex cannot break down into enzyme plus product.

Ejemplos de uso de uncompetitive
1. Thanks to the unions, British business had become hopelessly uncompetitive.
2. But they will discourage the upgrading of uncompetitive companies.
3. "We have become uncompetitive over the last five to six years.
4. Bundling all of these assets into one package has made the auction absolutely uncompetitive.
5. It can render production from entire sectors uncompetitive while stimulating development in others.